Aegyptin, a Novel Mosquito Salivary Gland Protein Specifically Binds to Collagen and Prevents its Interaction with Glycoprotein VI, Integrin α2β1 and von Willebrand Factor

Aegyptin, a Novel Mosquito Salivary Gland Protein Specifically Binds to Collagen and Prevents its Interaction with Glycoprotein VI, Integrin α2β1 and von Willebrand Factor Eric Calvo,1 Fuyuki Tokumasu,2 Osvaldo Marinotti,3 Jean-Luc Villeval,4 José M. C. Ribeiro,1 and Ivo M. B. Francischetti 1 1 Vector Biology Section, and 2 Biochemical and Biophysical Parasitology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA; 3 Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA; and 4 INSERM, U790, Université Paris XI, UMR 790, Institut Gustave Roussy Villejuif, France. Address correspondence: Ivo M. B. Francischetti, LMVR, NIAID, NIH, 12735 Twinbrook Pkwy. Rm 2E-28,Bethesda, MD 20852. Telephone: 301-402-2748; Fax: 301-480-2571; e-mail: [email protected] Running title: Mosquito collagen-binding protein